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Jörg Labahn

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Structural Biochemistry

"CSSB offers an attractive combination of biophysical methods for the structural characterization of proteins. Its dedication to targets which are directly relevant for human health, confers a healthy purpose"

Jörg Labahn, CSSB Group Leader

Collaborative Research in Infection Biology

Together with other CSSB researchers his group investigates proteins which are relevant in infection biology. Particularly CSSB‘s combined expertise in imaging and diffraction studies will enhance research opportunities in Membrane Protein Complexes.

A major goal for the next years is to analyze membrane protein structures. In particular, Labahn focuses on disease relevant human membrane proteins and developing an approach which allows collecting in-situ diffraction data from crystals obtained with his in-meso-phase crystallization method for X-ray crystallographic analysis.

Publications

Root-Bernstein R., et al. (2018) Adrenergic Agonists Bind to Adrenergic-Receptor-Like Regions of the Mu Opioid Receptor, Enhancing Morphine and Methionine-Enkephalin Binding: A New Approach to "Biased Opioids"? Int J Mol Sci; 19(1), 272

Yang G., et al. (2017) Influence of solubilization and AD-mutations on stability and structure of human presenilins. Sci Rep; 21;7(1):17970

Yang G., et al. (2017) Expression, purification, and preliminary characterization of humanpresenilin-2. Process Biochem; 64, 63

Tiruttani Subhramanyam U.K., et al. (2017) Structural basis for the regulatory interactions of proapoptotic Par-4. Cell Death Differ; 24(9):1540-1547

Gremer L., et al. (2017) Fibril structure of amyloid-ß(1-42) by cryoelectron microscopy. Science; 358(6359):116-119

Yu K., et al. (2017) High-efficient production and biophysical characterisation of nicastrin and its interaction with APPC100. Sci Rep; 7:44297

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