CSSB Seminar Series - Marco Galardini
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Meeting ID: 974 3405 0617
We are perhaps used to think of genetic variation in the context of human genetics; two individuals differ on average in about 5M sites in the genome, or about 0.8% of the whole genome. When thinking about bacteria, genetic variation takes a whole different scale: two E. coli strains may differ for up to 60% of their gene content, not even counting for SNPs. This implies that each bacterial species does not have a single genome, but rather a diverse ensemble of gene combinations, collectively termed as a pangenome. In this talk I will present a few approaches to study the relationship between this large genetic variation and variation in bacterial phenotypes and their application.