CSSB Centre for Structural Systems Biology
Suche
Home News & Events Events CSSB Seminar Series - Neil Ranson

CSSB Seminar Series - Neil Ranson

| Event

Join Zoom Meeting:
https://desy.zoom.us/j/82791280354
Meeting ID: 827 9128 0354
Passcode: 896275

Abstract:
In the human large intestine, bacteria within the microbiota grow in a soup of complex dietary polysaccharides, but the outer membrane of Gram-negative bacteria presents a prodigious barrier to the uptake of such nutrients. Using cryoEM we have been studying the mechanism of carbohydrate uptake by a novel class of transporters. I will describe the structure of a novel 'utilisome' complex for the integrated processing and transport of complex polysaccharides, and describe the biochemical and image processing approaches used to deal with heterogeneity and conformational change in this system, yielding new biological insight.