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Newsletter 14

We are happy to welcome Maya Topf and her group to CSSB and we are excited to share the results of some of our on-going SARS-CoV-2 research projects.

As 2020 draws to a close, we would like to thank our staff for their hard work and dedication and our colleagues for their continued support and collaboration. Wishing you all a happy and healthy holiday season and a wonderful new year!

CSSB NEWS

IMAGE: DESY

CSSB welcomes Maya Topf

On October 1, 2020, Prof. Maya Topf began working at the Centre for Structural Systems Biology CSSB. Prof. Topf has a joint call from the University Medical Center Hamburg-Eppendorf (UKE) and the Heinrich Pette Institute, Leibniz Institute for Experimental Virology (HPI) where she is head of the Research Department "Integrative Virology."

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One of the CASP14 targets: a duck hepatitis B virus capsid IMAGE: Dr.Tristan Cragnolini

An interview with CASP14 organizer Maya Topf

CSSB newest group leader, Maya Topf (HPI/UKE), was one of the five organizers of CASP14. In an interview, Maya shared her experience of being a part of CASP14 and her thoughts regarding the impact that AlphaFold will have on the scientific community.

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UPCOMING CSSB EVENTS

Elena Seiradake - 17 December

On 17 December at 11:30, Prof. Dr. Elena Seiradake from Oxford University will give a seminar entitled "Receptor-ligand complexes in the brain: combining structural and biological methods to understand the biology." All are welcome to join!

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IMAGE: Tim Gilberger

SAVE THE DATE: 7-9 December 2021

The 3rd CSSB International Symposium will now take place from 7-9 December 2021. The symposium entitled "Charting the landscape of infection: From entry to exit" will focus on a cross-disciplinary interrogation of the molecular mechanism of human infections.

SCIENTIFIC NEWS

IMAGE: Vadim Kotov, CC BY-SA 2.0

Protein Stability Analysis Made Easy With MoltenProt Software

Determining the stability of your protein prior to starting crystallography and electron cryo-microscopy experiments is now easier than ever thanks to a new software, MoltenProt, developed by CSSB scientist Vadim Kotov.

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IMAGE: Rayne Zaaymant-Gallant/EMBL

Scientists identify sybodies to combat COVID-19

CSSB scientists Christian Löw and Martin Hällberg and their collaborators have identified sybodies with the potential to neutralise the coronavirus SARS-CoV-2. Their work, published in Nature Communications, holds promise for treating COVID-19.

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IMAGE: Samuel Pazicky/EMBL

How deadly parasites glide into human cells

The CSSB groups of Christian Löw (EMBL) and Tim Gilberger (BNITM, UHH) reveal insights into the molecular structure of proteins involved in the gliding movements used by parasites to invade human host cells.

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IMAGE: Benjamin Vollmer

New insights into the herpes virus fusion process upon entry into the host cell

In a collaborative study conducted by the Heinrich Pette Institute, Leibniz Institute for Experimental Virology (HPI), the Centre for Structural Systems Biology (CSSB), the University of Oxford, the Birkbeck University of London, the Friedrich Loeffler Institute and the Institut Pasteur, the fusion process of herpes viruses with the host cell during cell entry was analyzed in detail using a multi-methodological approach.

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IMAGE: CDC/ Alissa Eckert, MS; Dan Higgins, MAMS

Antiviral drug, Favipiravir, could kill SARS-CoV-2 viral genome

CSSB Scientific Director, Chris Meier (UHH), and his postdoc Johanna Huchting were involved in a collaborative study with researchers from AFMB-CNRS, the University of Aix-Marseille, Universität Hamburg, and Colorado State University that reported the first detailed kinetic and mechanistic analysis of SARS-CoV-2's polymerase enzyme.

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IMAGE: Martin Hällberg

Alpaca nanobody neutralizes the SARS-CoV-2 spike protein

CSSB Research Hotel scientist, Martin Hällberg and collaborators from the Karolinska Institutet have demonstrated that an alpaca nanobody effectively neutralizes the SARS-CoV-2 spike protein.

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Contact Information

Centre for Structural Systems Biology (CSSB)
c/o DESY, Building 15
Notkestr. 85
22607 Hamburg
Germany
E-mail: info@cssb-hamburg.de

To find out more about CSSB please visit our website:
www.cssb-hamburg.de
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