CSSB Seminar Series - FRANK DIMAIO
Abstract:
The machine-learning structure prediction tools AlphaFold and RoseTTAfold have dramatically simplified low-resolution cryoEM map interpretation. Following this, we describe three tools our lab has developed in conjunction with these approaches. First, we describe novel machine-learning methodology for detecting errors in models built against low-resolution cryoEM density. Next, we describe tools for modelling ligands into low-resolution cryoEM density. Finally, we describe our efforts at adding to RoseTTAFold the ability to predict the structure of protein/nucelic-acid complexes.
Join Zoom Meeting:
https://desy.zoom.us/j/68894504419
Meeting ID: 688 9450 4419
Passcode: 535607
