Publications
2022
Zhu X, Xie X, Das H, Tan BG, Shi Y, Al-Behadili A, Peter B, Motori E, Valenzuela S, Posse V, Gustafsson CM, Hällberg BM, Falkenberg M. (2022) Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization. Cell. 2022. S0092-8674(22)00590-6. doi: 10.1016/j.cell.2022.05.006.
Hanke L, Das H, Sheward DJ, Perez Vidakovics L, Urgard E, Moliner-Morro A, Kim C, Karl V, Pankow A, Smith NL, Porebski B, Fernandez-Capetillo O, Sezgin E, Pedersen GK, Coquet JM, Hällberg BM, Murrell B, McInerney GM. (2022) A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.Nat Commun.13(1):155. doi: 10.1038/s41467-021-27610-z.
2021
Hanke L, Das H, Sheward DJ, Perez Vidakovics L, Urgard E, Moliner-Morro A, Kim C, Karl V, Pankow A, Smith NL, Porebski B, Fernandez-Capetillo O, Sezgin E, Pedersen GK, Coquet JM, Hällberg BM, Murrell B, McInerney GM (2021) A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo. bioRxiv 2021.03.20.436243; doi: https://doi.org/10.1101/2021.03.20.436243
Valentín Gesé G, Shahzad S, Pardo-Hernández C, Wramstedt A, Falkenberg M, Hällberg BM (2021) A dual allosteric pathway drives human mitochondrial Lon. bioRxiv 2021.06.09.447696; doi: https://doi.org/10.1101/2021.06.09.447696
Cipullo M, Gesé GV, Khawaja A, Hällberg BM, Rorbach J (2021) Structural basis for late maturation steps of the human mitoribosomal large subunit. Nat Commun. 12(1):3673. doi: 10.1038/s41467-021-23617-8.
Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI (2021) Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science.371(6530):eabe6230 doi: 10.1126/science.abe6230.
2020
Custódio TF, Das H, Sheward DJ, Hanke L, Pazicky S, Pieprzyk J, Sorgenfrei M, Schroer M, Gruzinov A, Jeffries C, Graewert M, Svergun D, Dobrev N, Remans K, Seeger MA, McInerney GM, Murrell B, Hällberg MB, Löw C (2020) Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2. Nat Commun.11(1):4420. doi: 10.1038/s41467-020-19204-y.
Wu PS, Enervald E, Joelsson A, Palmberg C, Rutishauser D, Hällberg BM, Ström L. Genetics (2020) Posttranslational Regulation of DNA Polymerase η, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. genetics.303494.2020. doi: 10.1534/genetics.120.303494.
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hällberg BM, Murrell B, McInerney GM (2020) An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction. Nat Commun.11(1):4420. doi: 10.1038/s41467-020-18174-5.
2017
Reinhard L, Sridhara S, Hällberg BM. (2017) The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria. Nucleic Acids Res 45:12469-12480. doi: 10.1093/nar/gkx902
Walldén K, Nyman T, Hällberg BM (2017) SnoN Stabilizes the SMAD3/SMAD4 Protein Complex. Sci Rep 7, 46370. doi: 10.1038/srep46370.
2015
Lapkouski M, Hällberg BM (2015) Structure of mitochondrial poly(A) RNA polymerase reveals the structural basis for dimerization, ATP selectivity and the SPAX4 disease phenotype. Nucleic Acids Res 43:9065-9075. doi: 10.1093/nar/gkv861.
Tan TC, Kracher D, Gandini R, Sygmund C, Kittl R, Haltrich D, Hällberg BM, Ludwig R, Divne C (2015) Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation. Nature communications 6:7542. doi: 10.1038/ncomms8542.
Reinhard L, Sridhara S, Hällberg BM (2015) Structure of the nuclease subunit of human mitochondrial RNase P. Nucleic Acids Res 43:5664-5672. doi: 10.1093/nar/gkv481
Posse V, Shahzad S, Falkenberg M, Hällberg BM, Gustafsson CM (2015) TEFM is a potent stimulator of mitochondrial transcription elongation in vitro. Nucleic Acids Res 43:2615-2624. doi: 10.1093/nar/gkv105.
2014
Hällberg BM, Larsson NG (2014) Making proteins in the powerhouse. Cell Metabolism 20:226-240. doi: 10.1016/j.cmet.2014.07.001.
Posse V, Hoberg E, Dierckx A, Shahzad S, Koolmeister C, Larsson NG, Wilhelmsson, LM, Hallberg, BM, Gustafsson CM (2014) The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation Nucleic Acids Res 42:3638-3647. doi: 10.1093/nar/gkt1397
2012
Spåhr H, Habermann B, Gustafsson CM, Larsson NG, Hällberg BM (2012) Structure of the MTERF4-NSUN4 complex that regulates mitochondrial ribosome biogenesis. PNAS 109, 15253-15258. doi: 10.1073/pnas.1210688109
2011
Cámara Y, Asin-Cayuela J, Park CB, Metodiev MD, Shi Y, Ruzzenente B, Kukat C, Habermann B, Wibom R, Hultenby K, Franz T, Erdjument-Bromage H, Tempst P, Hällberg BM, Gustafsson CM, Larsson NG (2011) MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell Metabolism. 13, 527-539.
Busam RD, Thorsell AG, Flores A, Hammarström M, Persson C, Öbrink B, Hällberg BM (2011) Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B). J. Biol. Chem. 286, 4511-4516. Highlighted in Nature Structural and Molecular Biology 18, 5.
Hällberg BM, Larsson NG (2011) TFAM forces mtDNA to make a U-turn. Nature Struct Mol Biol. 18, 1179-1181.
2010
Spåhr H, Samuelsson T, Hällberg BM, Gustafsson CM (2010) Structure of mitochondrial transcription termination factor 3 reveals a novel nucleic acid-binding domain. Biochem Biophys Res Commun. 397, 386-90.
2009
Thorsell AG, Persson C, Gräslund S, Hammarström M, Busam RD, Hällberg BM (2009) Crystal structure of human diphosphoinositol phosphatase 1. Proteins. 77, 242-246.
Seif E, Hällberg BM (2009) RNA-protein mutually induced Fit: Structure of E. coli isopentenyl-tRNA transferase in complex with tRNA(Phe). J. Biol. Chem. 284, 6600-6604.
2008
Thorsell AG, Persson C, Voevedskaya N, Busam RD, Hammarstrom M, Gräslund S, Gräslund A, Hällberg BM (2008) Structural and biophysical characterisation of human myo-inositol oxygenase. J. Biol. Chem. 283, 15209-15216.
Gräslund S, Nordlund P, Weigelt J, Hallberg BM, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, Park HW, Savchenko A, Yee A, Edwards A#, Vincentelli R, Cambillau C, Kim R, Kim SH, Rao Z, Shi Y, Terwilliger TC, Kim CY, Hung LW, Waldo GS, Peleg Y, Albeck S, Unger T, Dym O, Prilusky J, Sussman JL, Stevens RC, Lesley SA, Wilson IA, Joachimiak A, Collart F, Dementieva I, Donnelly MI, Eschenfeldt WH, Kim Y, Stols L, Wu R, Zhou M, Burley SK, Emtage JS, Sauder JM, Thompson D, Bain K, Luz J, Gheyi T, Zhang F, Atwell S, Almo SC, Bonanno JB, Fiser A, Swaminathan S, Studier FW, Chance MR, Sali A, Acton TB, Xiao R, Zhao L, Ma LC, Hunt JF, Tong L, Cunningham K, Inouye M, Anderson S, Janjua H, Shastry R, Ho CK, Wang D, Wang H, Jiang M, Montelione GT, Stuart DI, Owens RJ, Daenke S, Schütz A, Heinemann U, Yokoyama S, Büssow K, Gunsalus KC (2008) Protein production and purification. Nature Methods 5, 135-146.
2007
Vilhelmsson M, Selander C, Zargari A, Rasool O, Achour A, Scheynius A, Hällberg BM (2007) Crystal structure of the major Malassezia sympodialis allergen reveals a β-propeller fold: A novel fold among allergens. J. Mol. Biol 369, 1079-1086.
2006
Bakali MA, Herman MD, Johnson KA, Kelly A, Wieslander Å, Hällberg BM, Nordlund P (2006) Crystal structure of YegS, a homologue to mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site. J. Biol. Chem. 282, 19644-19652.
Busam RD, Thorsell AG, Flores A, Hammarstrom M, Persson C, Hällberg BM First structure of a eukaryotic phosphohistidine phosphatase. (2006) J. Biol. Chem. 281, 33830-33834.
Kujawa M, Ebner H, Leitner C, Hällberg BM, Prongjit M, Sucharitakul J, Ludwig R, Rudsander U, Peterbauer C, Chaiyen P, Haltrich D, Divne C. (2006) Structural basis for substrate binding and regioselective oxidation of monosaccharides at C3 by pyranose 2-oxidase. J. Biol. Chem. 281 35104-35115.
Hällberg BM, Ericsson UB, Johnson KA, Møller Andersen N, Douthwaite S, Nordlund P, Erlandsen H (2006) The structure of YebU, an RNA m5C methyltransferase from E.coli reveals a C-terminal RNA-recruiting PUA domain. J. Mol. Biol. 360, 774-787.
Ericsson UB, Hällberg BM, DeTitta GT, Dekker N, Nordlund P (2006) Thermofluor based high-throughput stability optimisation of proteins for structural and functional studies. Analytical Biochemistry 357, 289-298.
Johnson KA, Stahl A, Bhushan S, Hällberg BM, Glaser E, Eneqvist T (2006) The closed structure of presequence protease PreP forms a unique 10 000 A(3) chamber for proteolysis. EMBO J., 25, 1977-1986.
Bakali MA, Nordlund P, Hällberg BM (2006) Expression, purification, crystallization and preliminary diffraction studies of the mammalian DAG kinase homologue YegS from Escherichia coli. Acta Cryst. F, 62, 295-297.
Zamocky M, Ludwig R, Peterbauer C, Hällberg BM, Divne C, Nicholls P, Haltrich D (2006) Cellobiose dehydrogenase - a flavocytochrome from wood-degrading, phytopathogenic, and saprothrophic fungi. Current Protein and Peptide Science. 7, 255-280.
Vilhelmsson MS, Hällberg BM, Rasool O, Zargari A, Scheynius A, Achour A (2006) Crystallization and preliminary crystallographic study of the yeast Malassezia sympodialis allergen Mala s 1. Acta Cryst. F, 62, 97-99. Shared contribution.
2005
Hopfmann KH, Hällberg BM, Hihmo F (2005) Catalytic mechanism of Limonene Epoxide hydrolase, a theoretical study. JACS 127, 14339-14447.
2004
Hällberg BM, Leitner C, Haltrich D, Divne C (2004) Crystal Structure of the 270 kDa homotetrameric lignin degrading enzyme pyranose 2-oxidase J. Mol. Biol. 341, 781-796.
Zamocky M, Hällberg M, Ludwig R, Divne C, Haltrich D (2004) Ancestral gene fusion in cellobiose dehydrogenase reflects a specific evolution of GMC oxidoreductases in fungi. Gene 338, 1-14.
Eriksson UB, Nordlund P, Hällberg BM (2004) X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold. FEBS Lett. ,565, 59-64.
Ericsson UB, Andersson ME, Engvall B, Nordlund P, Hällberg BM (2004) Expression, purification, crystallization and preliminary diffraction studies of the tRNA pseudouridine synthase TruD from Escherichia coli. Acta Crystallogr D. 60, 775-776.
Hällberg BM, Leitner C, Haltrich D, Divne C (2004) Crystallization and preliminary X-ray diffraction analysis of pyranose 2-oxidase from the white-rot fungus Trametes multicolor. Acta Crystallogr D. 60, 197-199.
2003
Rotsaert FAS, Hällberg BMS, de Vries S, Moenne-Loccoz P, Divne C, Renganathan V, Gold MH (2003) Biophysical and structural analysis of a novel heme B iron ligation in the flavocytochrome cellobiose dehydrogenase. J. Biol. Chem. 278, 33224-33231. S Shared contribution.
Arand M, Hällberg BM, Zou J, Bergfors T, Oesch F, van der Werf MJ, de Bont JA, Jones TA, Mowbray SL (2003) Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site. EMBO J. 22, 2583-2592.
Campanacci V, Lartigue A, Hällberg BM, Jones TA, Giudici-Orticoni MT, Tegoni M, Cambillau C (2003) Moth chemosensory protein exhibits drastic conformational changes and cooperativity on ligand binding. PNAS 100, 5069-5074.
Mason MG, Nicholls P, Divne C, Hällberg BM, Henriksson G, Wilson MT (2003) The heme domain of cellobiose oxidoreductase: a one-electron reducing system. Biochim. Biophys. Acta 1604, 47-54.
Hällberg BM, Henriksson G, Pettersson G, Vasella A, Divne C (2003) Mechanism of the reductive half-reaction in cellobiose dehydrogenase. J. Biol. Chem. 278, 7160-7166.
2002
Hällberg BM, Henriksson G, Pettersson G, Divne C (2002) Crystal structure of the flavoprotein domain of the extracellular flavocytochrome cellobiose dehydrogenase. J. Mol. Biol. 315, 421-434.
Raices M, Montesino R, Cremata J, Garcia B, Perdomo W, Szabo I, Henriksson G, Hällberg BM, Pettersson G, Johansson G (2002) Cellobiose quinone oxidoreductase from the white rot fungus Phanerochaete chrysosporium is produced by intracellular proteolysis of cellobiose dehydrogenase. Biochim. Biophys. Acta 1576, 15-22.
Yoshida M, Ohira T, Igarashi K, Nagasawa H, Aida K, Hällberg BM, Divne C, Nishino T, Samejima M (2001) Production and characterization of recombinant Phanerochaete chrysosporium cellobiose dehydrogenase in the methylotrophic yeast Pichia pastoris. Biosci. Biotechnol. Biochem. 65, 2050-2057.
2000
Zou J, Hällberg BM, Bergfors T, Oesch F, Arand M, Mowbray SL, Jones TA (2000) Structure of Aspergillus niger epoxide hydrolase at 1.8 Å resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases. Structure 8, 111-122.
Hällberg BM, Bergfors T, Bäckbro K, Pettersson G, Henriksson G, Divne C (2000) A new scaffold for binding of haem in the cytochrome domain of the extracellular flavocytochrome cellobiose dehydrogenase. Structure 8, 79-88.