Publications
2023
Srivastava S, Kolbe M (2023) Novel "GaEl Antigenic Patches" Identified by a "Reverse Epitomics" Approach to Design Multipatch Vaccines against NIPAH Infection, a Silent Threat to Global Human Health. ACS Omega. 2023 Aug 22;8(35):31698-31713. doi: 10.1021/acsomega.3c01909.
Srivastava S, Verma S, Kamthania M, Saxena AK, Pandey KC, Pande V, Kolbe M. (2023) Exploring the structural basis to develop efficient multi-epitope vaccines displaying interaction with HLA and TAP and TLR3 molecules to prevent NIPAH infection, a global threat to human health. PLoS One. 2023 Mar 15;18(3):e0282580. doi: 10.1371/journal.pone.0282580.
Flacht L, Lunelli M, Kaszuba K, Chen ZA, O' Reilly FJ, Rappsilber J, Kosinski J, Kolbe M (2023) Integrative structural analysis of the type III secretion system needle complex from Shigella flexneri. Protein Sci.e4595. doi: 10.1002/pro.4595
2021
Srivastava S, Verma S, Kamthania M, Kaur R, Badyal RK, Saxena AK, Shin HJ, Kolbe M, Pandey KC (2021) Structural Basis for Designing Multiepitope Vaccines Against COVID-19 Infection: In Silico Vaccine Design and Validation. JMIR Bioinform Biotech 1(1):e19371. doi: 10.2196/19371.
Srivastava S, Chatziefthymiou SD, Kolbe M. (2021) Vaccines Targeting Numerous Coronavirus Antigens, Ensuring Broader Global Population Coverage: Multi-epitope and Multi-patch Vaccines. Methods Mol Biol. 2410:149-175. doi: 10.1007/978-1-0716-1884-4_7
Wang C, Nehls C, Baabe D, Burghaus O, Hurwitz R, Gutsmann T, Bröring M, Kolbe M. (2021) Flagellin lysine methyltransferase FliB catalyzes a [4Fe-4S] mediated methyl transfer reaction. PLoS Pathog.17(11):e1010052. doi: 10.1371/journal.ppat.1010052
Strahlberg D, Kolbe M, Pagnini G (2021) Antibiotics Resistance Forecasting: A Comparison of Two Time Series Forecast Models. SIAM Undergraduate Research Online
Kotov V, Lunelli M, Wald J, Kolbe M, Marlovits TC (2021) Helical reconstruction of Salmonella and Shigella needle filaments attached to type 3 basal bodies. Biochemistry and Biophysics Reports 27:101039. https://doi.org/10.1016/j.bbrep.2021.101039
Stinn A , Furkert J, Kaufmann Stefan H E, Moura-Alves P, Kolbe M (2021) Novel Method for Quantifying AhR-Ligand Binding Affinities Using Microscale Thermophoresis: In biosensors-1106567. doi: 10.3390/bios11030060
2020
Srivastava S, Verma S, Kamthania M, Agarwal D, Saxena AK, Kolbe M, Singh S, Kotnis A, Rathi B, Nayar SA, Shin H-J, Vashisht K & Pandey KC (2020) Computationally validated SARS-CoV-2CTL and HTL Multi-Patch vaccines, designed by reverse epitomics approach, show potential to cover large ethnically distributed human population worldwide, Journal of Biomolecular Structureand Dynamics, doi: 10.1080/07391102.2020.1838329
Srivastava S, Verma S, Kamthania M, Kaur R, Badyal R K, Saxena A K, Shin H J, Kolbe M, Pandey KC (2020) Structural Basis for Designing Multiepitope Vaccines Against COVID-19 Infection: In Silico Vaccine Design and Validation JMIR Bioinformatics Biotechnol: 1(1):e19371. doi: 10.2196/19371
Horstmann JA, Lunelli M, Cazzola H, Heidemann J, Kühne C, Steffen P, Szefs S, Rossi C, Lokareddy RK, Wang C, Lemaire L, Hughes KT, Uetrecht C, Schlüter H, Grassl GA, Stradal TEB, Rossez Y, Kolbe M, Erhardt M (2020) Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion. Nat Commun: 11(1):2013. doi: 10.1038/s41467-020-15738-3.
Lunelli M, Kamprad A, Bürger J, Mielke T, Spahn CMT, Kolbe M (2020) Cryo-EM structure of the Shigella type III needle complex. PLoS Pathog:16(2):e1008263. doi: 10.1371/journal.ppat.1008263.
2019
Moura-Alves P, Puyskens A, Stinn A, Klemm M, Guhlich-Bornhof U, Dorhoi A, Furkert J, Kreuchwig A, Protze J, Lozza L, Pei G, Saikali P, Perdomo C, Mollenkopf HJ, Hurwitz R, Kirschhoefer F, Brenner-Weiss G, Weiner J, Oschkinat H, Kolbe M, Krause G, Kaufmann SHE (2019) Host monitoring of quorum sensing during Pseudomonas aeruginosa infection. Science: 366(6472). pii: eaaw1629. doi: 10.1126/science.aaw1629
Wang C, Lunelli M, Zschieschang E, Bosse J, Thuenauer R, Kolbe M (2019) Role of flagellar hydrogen bonding in Salmonella motility and flagellar polymorphic transition. Mol Microbiol: ahead of print doi: 10.1111/mmi.14377
Bernal I, Römermann J, Flacht L, Lunelli M, Uetrecht C, Kolbe M (2019) Structural analysis of ligand-bound states of the Salmonella type III secretion system ATPase InvC. Protein Sci 2019: 1-14. doi: 10.1002/pro.3704
Bernal I, Börnicke J, Heidemann J, Svergun D, Horstmann JA, Erhardt M, Tuukkanen A, Uetrecht C, Kolbe M (2019) Molecular organization of soluble type III secretion system sorting platform complexes. J Mol Biol pii: S0022-2836(19)30425-5 doi: 10.1016/j.jmb.2019.07.004
Liu H, Moura-Alves P, Pei G, Mollenkopf H-J, Hurwitz R, Wu X, Wang F, Liu S, Ma M, Fei Y, Zhu C, Koehler A-B, Oberbeck-Mueller D, Hahnke K, Klemm M, guhlich-Bornhof U, Ge B, Tuukkanen A, Kolbe M, Dorhoi A, Kaufmann SHE (2019) cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity. EMBO Rep 20: e46293 doi: 10.15252/embr.201846293
2017
Horstmann J A, Zschieschang E, de Diego J, Lunelli M, Rohde M, May T, Strowig T, Stradal T, Kolbe M, Erhardt M (2017) Flagellin phasedependent swimming on epithelial cell surfaces contributes to productive Salmonella gut colonisation. Cell Microbiol. e12739.
2016
Senerovic L, Brotcke-Zumsteg A, Kolbe M (2016) IpaB ion channels induce pyroptosis in macrophages, Shigella: Molecular and Cellular Biology, edited by Bill Picking.
2014
Moura-Alves P, Faé K, Houthuys E, Dorhoi A, Kreuchwig A, Furkert J, Barison N, Diehl A, Munder A, Constant P, Skrahina T, Guhlich-Bornhof U, Klemm M, Koehler A B, Bandermann S, Goosmann C, Mollenkopf H J, Hurwitz R, Brinkmann V, Fillatreau S, Daffe M, Tümmler B, Kolbe M, Oschkinat H, Krause G, Kaufmann S H (2014) AhR sensing of bacterial pigments regulates antibacterial defence. Nature, 512: 387-92.
Dohlich K, Brotcke-Zumsteg A, Goosmann C, Kolbe M (2014) A Substrate-Fusion Protein is Trapped inside the Type III Secretion System Channel in Shigella flexneri. PLoS Pathogens, e003881.
2013
Barison N, Gupta R, Kolbe M (2013) A sophisticated multi-step secretion mechanism: how the type 3 secretion system is regulated. Cellular Microbiology, 15: 1809-1817.
Demers J P, Sgourakis N G, Gupta R, Loquet A, Giller K, Riedel D, Laube B, Kolbe M, Baker D, Becker S, Lange A (2013) The Common Structural Architecture of Shigella flexneri and Salmonella typhimurium Type Three Secretion Needles. PLoS Pathogens, e100324.
2012
Senerovic L, Tsunoda SP, Gossmann C, Brinkmann V, Zychlinsky A, Meissner F, Kolbe M (2012) Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophages. Cell Death & Disease, e384.
Mounier J, Boncompain G, Senerovic L, Lagache T, Chrétien F, Perez F, Kolbe M, Olivo-Marin JC, Sansonetti P J, Sauvonnet N (2012) Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion. Cell Host & Microbe, 12: 381-389.
Loquet A, Sgourakis N G, Gupta R, Giller K, Riedel D, Goosmann C, Griesinger C, Kolbe M, Baker D, Becker S, Lange A (2012) Atomic model of the type III secretion system needle. Nature, 486: 276-279
Barison N, Lambers J, Hurwitz R, Kolbe M (2012) Interaction of MxiG with the Cytosolic Complex of the Type III Secretion System Controls Shigella Virulence. FASEB J, 26:1717-1726.
2011
Lunelli M, Hurwitz R, Lambers J, Kolbe M (2011) Crystal Structure of SipD-PrgI: Insight into the Open State of the Type Three Secretion System Needle Tip and its Interaction with Host Ligands. PLoS Pathogens, 7: 1-12.
2010
Lokareddy R K, Lunelli M, Eilers B, Wolter V, Kolbe M (2010) Combination of Two Separate Binding Domains Defines Stoichiometry between Type III Secretion System Chaperone IpgC and Translocator Protein IpaB. J. Biol. Chem., 285: 39965-39975.
Poyraz O, Schmidt H, Seidel K, Delissen F, Ader C, Tenenboim H, Goosmann C, Laube B, Thünemann A F, Zychlinsky A, Baldus M, Lange A, Griesinger C, Kolbe M (2010) Protein refolding is required for assembly of the type three secretion needle. Nat. Struct. Mol. Biol., 17: 788-792.
2009
Lunelli M, Lokareddy R K, Zychlinsky A, Kolbe M (2009) IpaB-IpgC interaction defines binding motif for type III secretion translocator. Proc. Natl. Acad. Sci., 106: 9661-9666.
2008
Averhoff P, Kolbe M, Zychlinsky A, Weinrauch Y (2008) Single residue determines the specificity of neutrophil elastase for Shigella virulence factors. J. Mol. Biol., 377: 1053-1066.
2007
Ernst O P, Gramse V, Kolbe M, Hofmann K P, Heck M (2007) Monomeric G protein-coupled receptor rhodopsin in solution activates its G protein transducin at the diffusion limit. Proc. Natl. Acad. Sci., 104: 10859- 10864.
2006
Blasig I E, Winkler L, Lassowski B, Mueller S L, Zuleger N, Krause E, Krause G, Gast K, Kolbe M, Piontek J (2006) On the self-association potential of transmembrane tight junction proteins. Cell. Mol. Life Sci., 63: 505- 514.
Schubert M, Kolbe M, Kessler B, Oesterhelt D, Schmieder P (2002) Heteronuclear multidimensional NMR spectroscopy of solubilized membrane proteins: resonance assignment of native bacteriorhodopsin. Chembiochem, 4: 1019-1023.
2002
Kolbe M (2002) Röntgenographische und spektroskopische Charakterisierung der lichgetriebenen Ionenpumpe Halorhodopsin aus Halobacterium salinarum.
2000
Paula S, Tittor J, Kolbe M, Oesterhelt D (2000) Spectroscopic studies on crystals from bacterio- and halorhodopsin. Biophys. J., 78: 286.
Kolbe M, Besir H, Essen L O, Oesterhelt D (2000) Structure of the Light- Driven Chloride Pump Halorhodopsin at 1.8 Å Resolution. Science, 288: 1390– 1396